Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 13, 2026Journal of Clinical InvestigationOpen Access

Lymphatic dysfunction and ZFP36 deficiency contribute to myxomatous valve degeneration in Marfan Syndrome mice

View Full Paper
Ask AI
Bookmark
Share

Authors

CTCan TanZRZiyou RenSKShreya Kurup

Discussion

Loading...

Member takes

Overview

Randomized trial shows lymphatic dysfunction contributes to myxomatous degeneration in MFS, indicating potential therapeutic targets.

Key Points

  • This research aims to determine the role of lymphatic vessel dysfunction in myxomatous degeneration of the mitral valve in mice with Marfan syndrome.
  • Utilized Fbn1 mutant mice as a model for Marfan syndrome
  • Administered VEGF-C156S and FTY720 to assess effects on lymphatic function and valve conditions
  • Evaluated lymphatic and valvular endothelial cell characteristics through immunohistochemistry
  • VEGF-C156S treatment increased LV density in mitral valves and improved MDMV symptoms
  • FTY720 treatment reduced immune infiltration and restored lymphatic drainage in valves
  • Fbn1 mutant mitral valves exhibited disorganized endothelial cells and reduced ZFP36 expression

Cite This Study

Tan et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf4dafaef96ed7f056f5bhttps://doi.org/10.1172/jci195507
View Full Paper
Ask AI
Bookmark
Share