Zoledronic Acid in the Management of Melorheostosis of Radius and Ulna – A Rare Case Report with Literature Review

Introduction: Melorheostosis is an exceptionally rare mesodermal mixed sclerosing bone dysplasia that sometimes affects the surrounding soft tissue. There are no established guidelines for its management, as it is not a curable condition. Treatment primarily focuses on symptom relief and necessitates a coordinated multimodal approach involving orthopedics, physical medicine and rehabilitation, and pain management to achieve optimal results. Bisphosphonates have shown efficacy in this condition, alleviating pain and reducing disease severity. The literature contains only nine reports concerning the use of zoledronate in the treatment of melorheostosis. Case Report: We report a case involving a 24-year-old female diagnosed with melorheostosis affecting the radius and ulna, accompanied by subcutaneous hemangiomatosis, which was effectively managed with intravenous zoledronate and physiotherapy. Conclusion: This case report emphasizes the key characteristics of melorheostosis, the involvement of soft-tissues in this condition, and the application of zoledronate in its treatment, while highlighting the need for and potential of future research in this area.