Activatable Naphthalimide-Based Fluorescent Probe for Hydrogen Peroxide Detection: Visualizing Microcystin-LR Induced Oxidative Stress in Zebrafish and Hepatocyte Injury Mechanism

Linmin Nie; Ruiqin Zhang; Suyu Liu; Kexin Mu; Tingting Zhao; Xueping Hu; Xingliang Song; Xiaohong Liu; Xueyong Jin; Xiaoyan Wang; Yan Huang; Lingxin Chen

doi:10.1039/d6an00524a

January 1, 2026The Analyst

Activatable Naphthalimide-Based Fluorescent Probe for Hydrogen Peroxide Detection: Visualizing Microcystin-LR Induced Oxidative Stress in Zebrafish and Hepatocyte Injury Mechanism

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Key Points

This research aims to develop a fluorescent probe to detect hydrogen peroxide and visualize oxidative stress caused by microcystin-LR in aquatic organisms.
Utilized a naphthalimide-based fluorescent probe for hydrogen peroxide detection.
Investigated oxidative stress using zebrafish and hepatocyte models.
Conducted in vivo and in vitro assays to determine the effects of microcystin-LR exposure.
The fluorescent probe effectively detected hydrogen peroxide with improved sensitivity.
Zebrafish exhibited significant oxidative stress markers following microcystin-LR exposure.
Hepatocyte injury correlated with elevated levels of reactive oxygen species.

Implication

Study visualizes oxidative stress in zebrafish exposed to microcystin-LR, suggesting health risks.

Abstract

Microcystin-LR (MC-LR), a toxic cyanotoxin, accumulates in fish through uptake, posing severe threats to fisheries safety and human health. The interaction between MC-LR and aquatic fish induces oxidative stress, which...

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Cite This Study

Nie et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf665faef96ed7f05822d https://doi.org/10.1039/d6an00524a

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Activatable Naphthalimide-Based Fluorescent Probe for Hydrogen Peroxide Detection: Visualizing Microcystin-LR Induced Oxidative Stress in Zebrafish and Hepatocyte Injury Mechanism

Key Points

Implication

Abstract

Discussion

Cite This Study

Activatable Naphthalimide-Based Fluorescent Probe for Hydrogen Peroxide Detection: Visualizing Microcystin-LR Induced Oxidative Stress in Zebrafish and Hepatocyte Injury Mechanism

Key Points

Implication

Abstract

Discussion

Cite This Study

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