The framework proposes a unified theory of cancer development, indicating critical regulatory failures in tissues.
Final v1.0 of the Tissue Governance Failure Framework (TGFF), a unified systems-level theory of carcinogenesis integrating Repair Exhaustion, the SPDS/Dual-Hit Model, and the Quarantine Capsule Hypothesis. The framework proposes that cancer is a disease of tissue governance — the progressive failure of multicellular systems coordinating repair, cellular identity, apoptotic compliance, and immune surveillance. Generates 17 specific, falsifiable predictions. Published on Zenodo: https://doi.org/10.5281/zenodo.20650231
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Mohammed Fuad Yousef (2026) studied this question.
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