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June 1, 2026International Journal of Rheumatic Diseases

Postpartum Macrophage Activation Syndrome With Fulminant Hepatitis, a Rare and Life‐Threatening Complication of Primary Sjögren's Syndrome

Ziqiao Zhang Ziqiao Zhang Yong Fan Yan Geng Zhuoli Zhang Zhuoli Zhang

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Key Points

To report a rare case of postpartum macrophage activation syndrome leading to fulminant hepatitis in a patient with primary Sjögren's syndrome.
Case report detailing the clinical presentation and outcomes
Patient diagnosed with primary Sjögren's syndrome
Assessment of liver function and immune response
Patient experienced severe liver dysfunction associated with macrophage activation
Rapid clinical deterioration required intensive medical intervention
Fulminant hepatitis presented as a rare manifestation of postpartum complications in Sjögren's syndrome

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Implication

Case report highlights a rare life-threatening complication of primary Sjögren's syndrome in postpartum individuals, underscoring its significance.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf6d7faef96ed7f058798 https://doi.org/10.1111/1756-185x.70726

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Atypical Presentation of Macrophage Activation Syndrome Associated with Primary Sjogren\'s Syndrome2024
2Acute Heart Failure in the Course of Macrophage Activation Syndrome Due to Newly Diagnosed Systemic Lupus Erythematosus: Case Presentation and Literature Review2024 · 2 citations
3Hepatic Involvement in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome: Clinical and Therapeutic Insights From 2 CasesOriginal Research · 2026
4Coexistence of Macrophage Activation Syndrome, Systemic Lupus Erythematosus, and Hepatitis B: A Management Challenge2024
5Early Onset Neonatal Sepsis Induced Macrophage Activation Syndrome2025

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Unleashing the Cytokine Storm: A Case of Macrophage Activation Syndrome in Systemic Lupus Erythematosus2024
New-onset systemic lupus erythematosus presenting with macrophage activation syndrome: A case report of rare and life-threatening complication2026
Macrophage activation syndrome: a lifetrheatening complication in a 44 year old woman2024

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