Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 13, 2026GenesOpen Access

Integrative Analysis of Oxidative Stress and Cellular Senescence Pathways in Chronic Obstructive Pulmonary Disease

View Full Paper
Ask AI
Bookmark
Share

Authors

YTYanina TimashevaGKG. F. KorytinaVMV. A. Markelov

Discussion

Loading...

Member takes

Overview

Randomized trial investigates genetic contributions to lung function impairment in COPD, suggesting pathways for risk prediction.

Key Points

  • This research aims to explore the role of genetic variation in oxidative stress and senescence pathways in COPD susceptibility and lung function.
  • Analyzed 33 single-nucleotide variants in 747 COPD patients and 703 controls.
  • Used regression models to assess genetic associations with disease and lung function.
  • Constructed polygenic scores and evaluated their predictive power using ROC and NRI analyses.
  • Strongest association found for PIK3R1 rs831125 (OR = 2.31, p = 2.53 × 10−10).
  • Variants in NFE2L2, PIK3R1, and others linked to impaired pulmonary function.
  • Weighted polygenic score improved prediction of disease risk (AUC 88.1%, 95% CI 86.3–89.8%; p = 2.21 × 10−28).

Cite This Study

Timasheva et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf776faef96ed7f058aachttps://doi.org/10.3390/genes17060685
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oxidative stress-associated genes TPPP3 and VEGFA in COPD revealed by bulk and single-cell sequencing analysis2026
  2. 2Genetic and Molecular Interconnections Between Chronic Obstructive Pulmonary Disease and Osteoporosis: Insights from Single-Cell and Mendelian Randomization Analyses2026 · 1 citations
  3. 3Deciphering the Genetic Architecture of Chronic Obstructive Pulmonary Disease (COPD): Insights from the UK Biobank and Mendelian Randomization Analysis2024
  4. 4The Role of Programmed Cell Death–Related Genes in Asthma, Chronic Obstructive Pulmonary Disease, and Lung Function: A Multi-Omics Mendelian Randomization Study2026
  5. 5D30-13 Metabolomic Signatures of COPD: Insights From Comparative Analysis With Healthy Controls2026