Calcium (Ca 2+ ) ion microdomains are subcellular regions of high Ca 2+ concentration that develop rapidly near open Ca 2+ channels in the plasma membrane or internal stores and generate local regions of high Ca 2+ concentration. These microdomains are remarkably versatile in that they activate a range of responses that differ enormously in both their temporal and spatial profile. In this review, we describe how Ca 2+ microdomains generated by storeoperated calcium channels, a widespread and conserved Ca 2+ entry pathway, stimulate different signaling pathways, and how the spatial extent of a Ca 2+ microdomain can be influenced by Ca 2+ ATPase pumps.
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Barak et al. (2019) studied this question.
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