What question did this study set out to answer?

The study aims to detail a case of a pediatric patient with 1q25.3–q32.1 deletion and analyze related literature to enhance understanding of its clinical implications.

June 14, 2026Frontiers in PediatricsOpen Access

1q25.3–q32.1 deletion causing multisystem developmental delay: a case report and literature review

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Authors

LLLifang Liu RYRong Yu 张张伟忠

Discussion

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Overview

Case report highlights genotype–phenotype correlations in a child with 1q25.3–q32.1 deletion, suggesting early diagnosis improves outcomes.

Key Points

The study aims to detail a case of a pediatric patient with 1q25.3–q32.1 deletion and analyze related literature to enhance understanding of its clinical implications.
Clinical data collected from one case of 1q25.3–q32.1 deletion, including history and clinical examinations.
Literature search through PubMed, Embase, and other databases to compile cases and analyze genotype–phenotype associations.
Data extraction included clinical characteristics and genetic information from identified case reports.
Karyotype revealed a pathogenic 27.0-Mb deletion in the 1q25.3–q32.1 region.
Follow-up indicated persistent developmental delays in growth, motor skills, and language acquisition in the subject.
Literature review identified 31 cases, noting common features such as intrauterine growth restriction and microcephaly.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4429b1cc60ccdea8a0c2 https://doi.org/10.3389/fped.2026.1774631

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June 14, 2026Frontiers in PediatricsOpen Access

1q25.3–q32.1 deletion causing multisystem developmental delay: a case report and literature review

View Full Paper

Ask AI

Bookmark

Authors

LLLifang Liu RYRong Yu 张张伟忠

Discussion

Member takes

Overview

Case report highlights genotype–phenotype correlations in a child with 1q25.3–q32.1 deletion, suggesting early diagnosis improves outcomes.

Key Points

The study aims to detail a case of a pediatric patient with 1q25.3–q32.1 deletion and analyze related literature to enhance understanding of its clinical implications.
Clinical data collected from one case of 1q25.3–q32.1 deletion, including history and clinical examinations.
Literature search through PubMed, Embase, and other databases to compile cases and analyze genotype–phenotype associations.
Data extraction included clinical characteristics and genetic information from identified case reports.
Karyotype revealed a pathogenic 27.0-Mb deletion in the 1q25.3–q32.1 region.
Follow-up indicated persistent developmental delays in growth, motor skills, and language acquisition in the subject.
Literature review identified 31 cases, noting common features such as intrauterine growth restriction and microcephaly.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4429b1cc60ccdea8a0c2 https://doi.org/10.3389/fped.2026.1774631

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