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June 14, 2026Organic Letters0 citations

Synthesis of 3-Azetidinylpiperidines with Alkylidenemalononitrile

3-Azetidinylpiperidine-4-alkylidenemalononitrile and Related Building Blocks

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Authors

JSJuan M. SanfielAMAndrew T. McCabeANAleksandra Nilova

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Overview

Randomized trial explores novel cyclobutane structures in drug design, indicating new synthetic pathways.

Key Points

  • This research aims to develop new methods for synthesizing quaternary (hetero)cyclobutanes and linking them to other cycles for drug development.
  • Designed a novel approach utilizing allylic alkylation/exocyclic strain-release Cope rearrangement.
  • Optimized the synthesis for enantioselectivity with asymmetric allylic alkylation techniques.
  • Conducted functional group interconversion studies to create complex drug-like scaffolds.
  • Yielded uniquely linked heterocycles with alkylidenemalononitrile functional groups.
  • Achieved significant diastereoselectivity in the transformation of the functional groups.
  • Synthesis demonstrated a versatile approach applicable to various pharmaceutical compounds.
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Cite This Study

Sanfiel et al. (2026) studied this question.

synapsesocial.com/papers/6a2e44e4b1cc60ccdea8a40ehttps://doi.org/10.1021/acs.orglett.6c02310
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