International Session 3　　Larynx 1

Body(1， 085 characters): Objective : To determine if tocotrienol-rich vitamin E supplementation protects industrial workers from noise-induced oxidative stress and hearing loss.Methods : This randomized, double-blind, placebo-controlled trial involved 90 workers aged 50 years, exposed to occupational noise 78dB.Subjects were randomized to receive either vitamin E(300IU tocopherols＋30mg tocotrienols)or a placebo twice daily for 3 months.Evaluations included high-frequency Pure Tone Audiometry(4-8kHz)and serum oxidative markers : Malondialdehyde(MDA) , Glutathione Peroxidase(GPX) , and Superoxide Dismutase(SOD) .Results : Seventy-four subjects completed the study.The vitamin E group demonstrated a highly significant reduction in MDA levels(p＝0． 001) , indicating significant reduction in reactive oxygen species activities.Audiometric analysis revealed a significant improvement at 8kHz in the right ear(p＜0． 05)post-supplementation.No significant changes were observed in the placebo group.Variations in antioxidant enzymes suggested possible baseline dietary influences.Conclusion : Tocotrienol-rich vitamin E effectively mitigates systemic oxidative stress and offers potential otoprotection at specific high frequencies in noise-exposed workers.