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June 14, 2026iScienceOpen Access

HERC4 suppresses colorectal cancer progression by promoting STAT3 ubiquitination

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Authors

LJLanzhu Jiang秦秦凯迪JYJin Yuan

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Overview

Functional assays demonstrate HERC4's role in suppressing colorectal cancer progression via SOC3 ubiquitination, indicating potential for therapy.

Key Points

  • This research aims to explore the role of HERC4 in colorectal cancer progression and its relationship with STAT3.
  • Analyzed HERC4 expression in colorectal cancer tissues to assess patient prognosis.
  • Conducted functional assays to evaluate HERC4's effect on CRC cell proliferation in vitro and in vivo.
  • Examined the interaction between HERC4 and STAT3, focusing on ubiquitination at specific lysine residues.
  • HERC4 expression was significantly downregulated in colorectal cancer tissues, correlating with poor prognosis.
  • Functional assays revealed that reintroducing HERC4 decreased CRC cell proliferation both in laboratory conditions and in animal models.
  • HERC4 was shown to promote K48-linked ubiquitination of STAT3, leading to its proteasomal degradation, specifically targeting lysine 392.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/6a2e44e4b1cc60ccdea8a4f6https://doi.org/10.1016/j.isci.2026.116226
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