Novel method enhances catalyst activity and promotes deracemization in pharmaceutical production, suggesting significant advancements in chiral synthesis.
In the Research Article (e3464047), Weiwei Tang, Yanfeng Dang, Junbo Gong, and co-workers report a novel MOF-mediated heterogeneous catalysis strategy for enantiomerically pure pharmaceutical products. Their cocrystallization-induced deracemization method, based on MOF-confinement, successfully eliminates detrimental interactions while effectively maintaining high catalyst activity, thereby overcoming the long-standing incompatibility between homogeneous catalysts and chiral components in spontaneous deracemization.
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Su et al. (2026) studied this question.
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