Randomized trial investigates cyclosporine A's protective effects against rhabdomyolysis caused by wasp venom, suggesting new treatment options.
Key Points
This study investigates how the CypD-mPTP pathway contributes to wasp venom-induced rhabdomyolysis and evaluates the protective effects of cyclosporine A.
Rats were randomly assigned to five groups, including control and venom-treated groups.
Interventions included treatment with normal saline or cyclosporine A.
Histological and biochemical assessments were performed to evaluate muscle damage and inflammation.
The venom group exhibited significant increases in serum CK, AST, ALT, and Cr levels (P < 0.01).
Pro-inflammatory cytokines such as IL-2, IFN-γ, and TGF-β were also significantly elevated (P < 0.01).
Histological analysis revealed severe myofiber disruption, and CsA treatment markedly improved these injuries.