Pinpoint Closed Intra-Wound Continuous Negative Pressure and Irrigation Therapy for Irrigation Around Foreign Bodies: An Experimental Study

Objectives: Infected wounds with foreign bodies, including implants, usually require implant removal for healing. When removal is impractical, closure with muscle flaps often leads to abscesses or recurrent infection. Pinpoint closed intra-wound continuous negative pressure and irrigation therapy (pinpoint closed IW-CONPIT) was developed for localized irrigation around retained implants. This ex vivo study aimed to determine the optimal negative pressure and irrigation volume relative to implant size in an experimental model that mimicked a human soft tissue environment.