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This study aims to elucidate the mechanistic roots of efficiency and selectivity in photocatalytic systems driven by electron-donor-acceptor (EDA) interactions.

June 14, 2026Nature Communications0 citationsOpen Access

Unraveling the mechanistic origins of efficiency and stereoselectivity in EDA-mediated photocatalysis

MFMengchen Fu YLYi Luo LQLuyang Qin

Key Points

This study aims to elucidate the mechanistic roots of efficiency and selectivity in photocatalytic systems driven by electron-donor-acceptor (EDA) interactions.
Utilized femtosecond and nanosecond transient absorption spectroscopy.
Investigated the α-alkylation of aldehydes as a prototypical EDA system.
Mapped excited-state dynamics and radical generation pathways in real-time.
Established two radical-generation pathways: direct decay of singlet charge-transfer state and triplet charge-transfer mediated route.
Demonstrated rapid departure of Br- from A•- increases radical formation while decreasing unproductive recombination with D•+.
Highlighted that solvent-cage confinement enhances radical orientation, leading to high enantioselectivity.

Abstract

Visible-light-driven electron-donor-acceptor (EDA) photocatalysis holds transformative potential for asymmetric synthesis, yet its efficiency and selectivity are dictated by excited-state dynamics that have, until now, eluded direct observation. Here, we utilize femtosecond and nanosecond transient absorption spectroscopy to investigate a prototypical EDA system: asymmetric α-alkylation of aldehydes. Our real-time kinetic mapping successfully resolves the singlet charge-transfer state (¹CT), triplet charge-transfer state (3CT), and donor-acceptor radical pairs (D•+ and A•). We uncover two concurrent radical-generation pathways: direct decay of ¹CT and a 3CT-mediated route, which maximize reaction efficiency. Rapid Br- departure from A•- furnishes A•, suppresses unproductive charge recombination with D•+, while solvent-cage confinement preserves radical orientation, promoting in-cage coupling with high enantioselectivity. These findings establish a general mechanistic blueprint where ground-state pre-organization and excited-state dynamics are synergistically harnessed, offering a distinct paradigm to overcome diffusion-controlled limits for the rational design of advanced photocatalytic systems. The authors use femtosecond and nanosecond transient absorption spectroscopy to investigate a prototypical EDA system, asymmetric α-alkylation of aldehydes, enabling observation of excited-state dynamics.

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