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June 14, 2026Autophagy ReportsOpen Access

Seeing is believing: visualizing spatiotemporal lipophagic flux in vivo with the tfLiveDrop reporter mice

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Authors

SGSiqiao GongCYChen YangHLHuafeng Liu

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Overview

Randomized trial shows organ-specific lipophagy dynamics in vivo, indicating potential metabolic insights for diseases.

Key Points

  • The aim is to visualize and understand the regulation of lipophagy in living organisms using a novel reporter model.
  • Developed tfLiveDrop reporter mice with a pH-sensitive tandem fluorescent probe for in vivo studies.
  • Performed real-time, single-cell imaging to assess lipophagic flux across various organs.
  • Investigated the effects of type 2 diabetes on lipophagic activity in specific tissues.
  • Demonstrated pronounced organ heterogeneity in basal lipophagy with specific rates of flux observed.
  • Identified decreased lipophagic activity in organs affected by type 2 diabetes.
  • Revealed a developmental program that enhances lipophagy, facilitating renal metabolic maturation.

Cite This Study

Gong et al. (2026) studied this question.

synapsesocial.com/papers/6a2e45adb1cc60ccdea8ab20https://doi.org/10.1080/27694127.2026.2687045
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