Key result
Severe maternal morbidity rises ~26%, closely linked to advanced maternal age.
Why the study?
Severe maternal morbidity is a significant public health concern, prompting an analysis of its incidence, trends, causes, and pregnancy outcomes in Wuxi to inform clinical and public health strategies.
Observational (n=156,435)
Yes
The incidence of severe maternal morbidity in Wuxi has increased recently, driven by advanced maternal age and a shift towards moderate-risk pregnancies experiencing higher rates of adverse outcomes.
Provides baseline SMM incidence for surveillance benchmarking; leaves open causal drivers of the recent rise with advanced maternal age.
Background Severe maternal morbidity (SMM) is a significant public health concern. This study analyzed the incidence, trends, causes, and pregnancy outcomes of SMM in Wuxi to inform future clinical and public health strategies. Methods A retrospective analysis was conducted on 315 critical maternal cases identified from 156,435 deliveries in Wuxi between October 1, 2020, and September 30, 2024. Data were extracted from a citywide near-miss maternal surveillance system. Statistical analyses were performed using SPSS 25.0, employing chi-square tests and Cochran-Armitage trend tests to evaluate trends, and chi-square tests for comparisons between groups. Results The overall incidence of SMM was 0.20%. Initially, this rate remained stable at 0.19% across the first three cycles (P > 0.05); however, it significantly increased to 0.24% during the cycle from October 2023 to September 2024 (χ² = 5.24, P = 0.02). This increase was closely associated with a rise in the proportion of women of advanced maternal age (≥35 years), which reached 26.03% (χ² = 11.76, P = 0.001). Over time, the distribution of risk levels shifted. Initially, the high-risk group was dominant (63.29%), but in recent cycles, the moderate-risk group became more prominent (64.44%). The moderate-risk group was associated with a higher rate of adverse outcomes (25.00–25.71%) compared to the high-risk group (17.11–20.69%; χ² = 10.83, P = 0.01). Direct obstetric factors were the primary causes, accounting for 79.05% of cases, with obstetric hemorrhage being the most prevalent (53.97%). In contrast, the proportion of cases attributable to indirect obstetric factors increased from 17.81% to 26.67%, primarily due to heart disease and infectious diseases. Conclusion Improving maternal safety involves dynamic risk assessments, tiered referrals for moderate-risk pregnancies, better multidisciplinary management of complications, optimized emergency responses in primary care, and refined regional referral systems to reduce preventable SMM and mortality.
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Xu et al. (2026) conducted an observational in Severe maternal morbidity (SMM) (n=156,435). Time period (Oct 2023 - Sep 2024) vs. Previous three cycles (Oct 2020 - Sep 2023) was evaluated on Incidence of severe maternal morbidity (SMM) (p=0.02). The incidence of severe maternal morbidity significantly increased from 0.19% to 0.24% in the most recent cycle (P=0.02), closely associated with a rise in advanced maternal age.
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