Randomized trial examines hepatic inflammation due to low-dose arsenic and cadmium in a mouse model, indicating sex-dependent reactions.
Key Points
This research aims to understand the effects of low-dose arsenic and cadmium on hepatic inflammation and metabolic dysfunction associated with fatty liver disease in a murine model.
Utilized apolipoprotein E-knockout mouse model to explore sex differences in response to metal exposure.
Assessed hepatic steatosis and inflammation through gene expression and protein levels, particularly PLIN2 expression and immune cell infiltration.
Employed high-plex single-cell imaging (PhenoCycler) to analyze liver immune responses.