What question did this study set out to answer?

This research aims to clarify how iron deficiency, indicated by ferritin and transferrin saturation (TSAT), affects renal progression and mortality in patients with chronic kidney disease (CKD) and anemia.

June 14, 2026Kidney DiseasesOpen Access

Differential Associations of Iron Deficiency with Renal Progression and Mortality in Anemic Non-Dialysis-Dependent Chronic Kidney Disease

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This research aims to clarify how iron deficiency, indicated by ferritin and transferrin saturation (TSAT), affects renal progression and mortality in patients with chronic kidney disease (CKD) and anemia.
Conducted a multicenter retrospective cohort study utilizing data from the China Renal Data System.
Analyzed 40,667 hospitalized adults with anemia and non-dialysis-dependent CKD, tracking serum ferritin and TSAT levels.
Utilized multivariable Cox proportional hazards models and competing risk models for analysis.
22.85% of patients in the ferritin cohort experienced CKD progression, while 26.70% in the TSAT cohort did.
Ferritin ≤100 ng/mL was associated with a modestly lower risk of CKD progression (aHR 0.95, 95% CI 0.90-0.99).
TSAT ≤20% correlated with increased all-cause mortality risk (aHR 1.19, 95% CI 1.06-1.36).

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Implication

Multicenter cohort study reveals different impacts of ferritin and TSAT on renal outcomes in anemic non-dialysis-dependent CKD.

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4855b1cc60ccdea8c8f0 https://doi.org/10.1159/000552972

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Differential Associations of Iron Deficiency with Renal Progression and Mortality in Anemic Non-Dialysis-Dependent Chronic Kidney Disease

Key Points

Discussion

Implication

Cite This Study

Differential Associations of Iron Deficiency with Renal Progression and Mortality in Anemic Non-Dialysis-Dependent Chronic Kidney Disease

Key Points

Discussion

Implication

Cite This Study

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