Why the study?
The study sought to compare CVD risk reclassification using the 2023 PREVENT equations with and without the optional predictors HbA1c and UACR.
Does the use of enhanced PREVENT equations including HbA1c and UACR improve 10-year CVD risk estimation compared to base PREVENT equations in adults?
Population
8,293 adults aged 30 to 79 years in NHANES 2015-2020
Comparison
Enhanced PREVENT equations (including HbA1c and UACR) vs base PREVENT equations
Design
Cross-sectional study
Key result
Enhanced PREVENT equations including HbA1c and UACR yielded higher 10-year CVD risk estimates than base equations in adults with HbA1c ≥9.0% (17.8% vs 11.8%) and UACR ≥300 mg/g (36.1% vs 23.4%).
Authors
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Enhanced PREVENT equations may elevate 10-year CVD risk estimates in severe hyperglycemia; leaves open whether optional predictors improve stratification.
Cross-Sectional (n=8,293)
Does the use of enhanced PREVENT equations including HbA1c and UACR improve 10-year CVD risk estimation compared to base PREVENT equations in adults?
The inclusion of HbA1c and UACR in the PREVENT equations provides greater individualization of CVD risk estimation in adults with diabetes, but offers little benefit in populations without diabetes.
Wilson et al. (2026) conducted a cross-sectional in Cardiovascular disease (n=8,293). Enhanced PREVENT equations (including HbA1c and UACR) vs. Base PREVENT equations was evaluated on 10-year cardiovascular disease risk estimates. Enhanced PREVENT equations including HbA1c and UACR yielded higher 10-year CVD risk estimates than base equations in adults with HbA1c ≥9.0% (17.8% vs 11.8%) and UACR ≥300 mg/g (36.1% vs 23.4%).
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