Key result
Cortisol-producing adenoma significantly increased perirenal adipose tissue oxidative stress, inflammation, and fibrosis compared to normotensive controls.
Why the study?
Although corticosteroids are known to affect adipose tissue functions, little genetic information is available regarding perirenal adipose tissue from patients with cortisol-producing adenoma.
Does chronic exposure to glucocorticoids increase oxidative stress, inflammation, and fibrosis in perirenal adipose tissue?
Observational
Does chronic exposure to glucocorticoids increase oxidative stress, inflammation, and fibrosis in perirenal adipose tissue?
Chronic exposure to endogenous glucocorticoids from cortisol-producing adenomas increases oxidative stress, inflammation, and fibrosis in perirenal adipose tissue, potentially contributing to metabolic disturbances.
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May link glucocorticoid excess to adipose dysfunction; hypothesis-generating and requires human validation before clinical relevance.
Wu et al. (2019) conducted an observational in Cortisol-producing adenoma. Cortisol-producing adenoma vs. Normotension was evaluated on Inflammation, fibrosis and oxidative stress markers in perirenal adipose tissue. Cortisol-producing adenoma significantly increased perirenal adipose tissue oxidative stress, inflammation, and fibrosis compared to normotensive controls.
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