Human CD24+ dental papilla cells are competent seed cells for dentin-pulp regeneration via BMP2/SIRT1 axis

Cheng Liang; Zhi Liu; Jie Li; Cong Han; Gao Y; Bohuai Zhou; Qiuyu Chen; Fei Bi; Chengcheng Liao; Wu Wx; Tiantian Hu; Jingyi Zhang; Ding Bai; Yiping Chen; Zhonghan Li; Weidong Tian; Tian Chen

doi:10.1038/s41467-026-74348-7

June 12, 2026Nature CommunicationsOpen Access

Human CD24+ dental papilla cells are competent seed cells for dentin-pulp regeneration via BMP2/SIRT1 axis

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Key Points

This research aims to explore the potential of CD24+ dental papilla cells for effective dentin-pulp regeneration.
Isolated human CD24+ dental papilla cells (hDPCs) for analysis of regeneration potential.
Examined the role of BMP2 and SIRT1 in mitochondrial metabolism and signaling.
Investigated the regenerative capabilities of hDPCs in dental tissue engineering.
hDPCs demonstrated enhanced regeneration capacity linked to BMP2/SIRT1 signaling pathways.
Significant integration of mitochondrial metabolism was observed during the regeneration process.
hDPCs represent a viable cell source for advancing dental tissue engineering.

Implication

Demonstrates effective dentin-pulp regeneration using CD24+ DPCs, suggesting a novel approach for dental tissue engineering.

Abstract

hDPCs represent a regeneration-competent subpopulation that integrates mitochondrial metabolism and signaling crosstalk to enable coordinated dentin-pulp regeneration, representing a translationally relevant cell source for dental tissue engineering.

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Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/6a2f966ca1cfeec490827e6c https://doi.org/10.1038/s41467-026-74348-7

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Human CD24+ dental papilla cells are competent seed cells for dentin-pulp regeneration via BMP2/SIRT1 axis

Key Points

Implication

Abstract

Discussion

Cite This Study

Human CD24+ dental papilla cells are competent seed cells for dentin-pulp regeneration via BMP2/SIRT1 axis

Key Points

Implication

Abstract

Discussion

Cite This Study

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