Randomized trial demonstrates improved cognitive function in Alzheimer’s disease using targeted brain stimulation, indicating a potential new treatment approach.
Alzheimer’s disease (AD) is characterized by dysfunction of large-scale brain networks, particularly the default mode network (DMN) and working memory network (WMN), with pathology, atrophy, and disconnection in these networks closely associated with cognitive decline [1]. Disease progression has been proposed to involve cascading dysfunction across these networks [2], with posterior DMN regions affected early and prefrontal DMN and WMN regions increasingly involved over time. Given their pivotal roles, these hub regions may represent promising targets for circuit-based AD therapies.
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Xu et al. (2026) studied this question.
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