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June 15, 2026Scientific ReportsOpen Access

EZH2 as regulator of stemness signature and driver of esophageal squamous cell carcinomas

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Authors

FNFatemeh NourmohammadiMMMaryam M. MatinABAhmad Reza Bahrami

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Overview

Randomized trial investigates EZH2's role in tumor growth and chemotherapy resistance in esophageal squamous cell carcinoma, highlighting new therapy avenues.

Key Points

  • This research aims to elucidate the role of EZH2 in promoting cancer stem cell characteristics and tumor progression in esophageal squamous cell carcinoma.
  • Analyzed EZH2 expression and its association with stem cell markers using bioinformatics and gene expression assays.
  • Conducted functional analyses to evaluate self-renewal, proliferation, and resistance to chemotherapy agents.
  • Utilized xenograft models to assess the impact of EZH2 on tumor growth, metastasis, and angiogenesis.
  • EZH2 overexpression enhanced stemness features, promoting increased colony and sphere formation.
  • EZH2 increased tumor growth and metastasis in vivo, demonstrating significant effects on angiogenesis.
  • Targeting EZH2 with specific inhibitors resulted in suppressed tumor progression and improved survival rates.

Cite This Study

Nourmohammadi et al. (2026) studied this question.

synapsesocial.com/papers/6a2f97c8a1cfeec490828d54https://doi.org/10.1038/s41598-026-55157-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EZH2 Regulates the Proliferation-Senescence Balance and Tumor–Stromal Signaling in Lung Adenocarcinoma2026
  2. 2EZH2 Expression Is Associated With Sensitivity to Inhibitors and Promotes Malignancy in Endometrial Cancer Cells2026
  3. 3EZH2 Dysregulation and Its Oncogenic Role in Human Cancers2025 · 16 citations
  4. 4ESCO2’s oncogenic role in human tumors: a pan-cancer analysis and experimental validation2024 · 10 citations
  5. 5Sensitivity evaluation to EZH2 inhibitors and EZH2 functional analysis in endometrial cancer cell lines2025