Association of Weight and Body Composition on Cardiac Structure and Function in the ARIC Study (Atherosclerosis Risk in Communities)
Key result
Increasing body mass index, waist circumference, and body fat were associated with greater left ventricular mass and left atrial volume in both men and women (P<0.001).
Why the study?
Are body mass index, waist circumference, and percent body fat associated with abnormalities in cardiac structure and function in older adults free of coronary heart disease and heart failure?
Population
4,343 biracial older adults from the ARIC study, free of clinically overt coronary heart disease and heart…
Design
Cohort
Authors
Discussion
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Implication
Adiposity may mark subclinical remodeling risk in older adults without CVD; extends associations but leaves causal effects and interventions open.
Study Design
Type
Cohort (n=4,343)
Multicenter
Yes
Structured PICO
Are body mass index, waist circumference, and percent body fat associated with abnormalities in cardiac structure and function in older adults free of coronary heart disease and heart failure?
P
Population
4,343 older adults aged 69 to 82 years, free of coronary heart disease and heart failure, who underwent comprehensive echocardiography.
E
Exposure
Measures of obesity and body composition (body mass index, waist circumference, and percent body fat)
O
Outcome
Conventional and advanced measures of cardiac structure and function on comprehensive echocardiography (including left ventricular mass, left atrial volume indexed to height^2.7, LV geometry, global longitudinal strain, right ventricular end-diastolic area, and right ventricular fractional area change)surrogate
Main Result
p-value: p=<0.001
Obesity and increased body fat are associated with subclinical adverse cardiac remodeling and impaired systolic function, particularly in women, even in the absence of overt cardiovascular disease.
Cite This Study
Bello et al. (2016) conducted a cohort in Obesity (n=4,343). Obesity and body composition measures (BMI, waist circumference, percent body fat) was evaluated on Cardiac structure and function (including LV mass, LA volume, LV geometry, global longitudinal strain, and RV area) (p=<0.001). Increasing body mass index, waist circumference, and body fat were associated with greater left ventricular mass and left atrial volume in both men and women (P<0.001).