Key result
Rous sarcoma virus-transformed chicken embryo fibroblasts showed greatly reduced major tropomyosin 1 and increased relative amounts of tropomyosin 3a and 3b compared to normal cells.
Population
Chicken embryo fibroblasts (CEF) and Rous sarcoma virus-transformed CEF cells
Comparison
Rous sarcoma virus transformation vs Normal chicken embryo fibroblasts
Design
Preclinical
Authors
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Altered tropomyosin isoforms may drive cytoskeletal disruption in transformed fibroblasts; leaves open relevance to human cardiac cell remodeling.
Changes in tropomyosin isoform expression in Rous sarcoma virus-transformed cells may be responsible for the reduction of actin cables and alteration of cell shape.
Lin et al. (1985) studied Rous sarcoma virus transformation. Rous sarcoma virus transformation vs. Normal chicken embryo fibroblasts was evaluated on Tropomyosin isoform expression and actin-binding properties. Rous sarcoma virus-transformed chicken embryo fibroblasts showed greatly reduced major tropomyosin 1 and increased relative amounts of tropomyosin 3a and 3b compared to normal cells.
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