Key result
Rous sarcoma virus-transformed chicken embryo fibroblasts showed greatly reduced major tropomyosin 1 and increased relative amounts of tropomyosin 3a and 3b compared to normal cells.
Changes in tropomyosin isoform expression in Rous sarcoma virus-transformed cells may be responsible for the reduction of actin cables and alteration of cell shape.
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Altered tropomyosin isoforms may drive cytoskeletal disruption in transformed fibroblasts; leaves open relevance to human cardiac cell remodeling.
Lin et al. (1985) studied Rous sarcoma virus transformation. Rous sarcoma virus transformation vs. Normal chicken embryo fibroblasts was evaluated on Tropomyosin isoform expression and actin-binding properties. Rous sarcoma virus-transformed chicken embryo fibroblasts showed greatly reduced major tropomyosin 1 and increased relative amounts of tropomyosin 3a and 3b compared to normal cells.
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