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“Our study points to anti-Ro/SSA antibodies as a novel, epidemiologically relevant and potentially reversible cause of isolated AVB in adults, via an autoimmune-mediated functional interference with the L-type calcium channels. These findings have significant impact on antiarrhythmic therapies by avoiding or delaying pacemaker implantation.”
“Lazzerini et al provide clinical and experimental evidence that LTCC inhibition in atrioventricular nodal cells is a central mechanism of anti-SSA–mediated AVB”
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Lazzerini et al. (2026) studied this question.
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