The Chemistry of Lanthanides in Biology: Recent Discoveries, Emerging Principles, and Technological Applications

, but with unique twists-including cooperative metal binding to magnify the effects of small ionic radius differences-enabling selectivity. This Outlook summarizes the recent developments in this young but rapidly expanding field and looks forward to potential future discoveries, emphasizing continuity with principles of bioinorganic chemistry established by studies of other metals. We also highlight how a more thorough understanding of the central chemical question-selective lanthanide recognition in biology-may impact the challenging problems of sensing, capture, recycling, and separations of rare earths.