Population
Mouse models (HCN4CreERT2, -nuclear LacZ, and -H2BGFP mouse lines)
Design
Preclinical
Key result
HCN4 expression marked the first heart field at cardiac crescent stages and distinct cardiac conduction system precursors throughout embryonic development in mouse models.
Authors
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Facilitates HCN4 lineage tracing in mouse cardiac development; leaves open translation to human conduction disorders or biological pacemakers.
HCN4 is identified as a dynamic marker for the first heart field and cardiac conduction system precursors, facilitating lineage tracing and research into biological pacemakers.
Liang et al. (2013) studied Cardiac conduction system development. HCN4 lineage tracing was evaluated on HCN4 expression and lineage tracing. HCN4 expression marked the first heart field at cardiac crescent stages and distinct cardiac conduction system precursors throughout embryonic development in mouse models.