Key result
Gata4(+/-) mice exhibited short PR intervals indicative of accelerated AV conduction, demonstrating that Gata4 is a novel regulator of atrioventricular delay.
Population
Mice models (including Gata4+/- mice) used to study the developing atrioventricular conduction system
Design
Preclinical
Authors
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Gata4 variants merit human genetic studies of AV conduction; does not yet alter clinical practice.
This study identifies Gata4 as a novel transcriptional regulator of atrioventricular delay through its action on the Cx30.2 enhancer.
Munshi et al. (2009) studied Cardiac conduction abnormalities. Gata4 haploinsufficiency (Gata4+/-) vs. Wild-type was evaluated on PR interval and atrioventricular conduction. Gata4(+/-) mice exhibited short PR intervals indicative of accelerated AV conduction, demonstrating that Gata4 is a novel regulator of atrioventricular delay.
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