Key result
Pitx2c is required for the initial formation of pulmonary myocardial cells, while Nkx2-5 determines their distinct identity compared to the systemic venous return.
Population
Mice models (including Pitx2c-deficient mice, Nkx2-5 hypomorphic models, and genetic labeling models)
Comparison
Genetic modification vs Wild-type/control mice
Design
Preclinical
Authors
Loading...
Hypothesis-generating in mice for pulmonary myocardium origins; leaves open human AF relevance and therapeutic targeting.
Pitx2c and Nkx2-5 are essential for the formation and identity of the pulmonary myocardium, providing insights into the cellular origins of a key source of atrial fibrillation.
Mommersteeg et al. (2007) studied Pulmonary myocardium formation. Pitx2c deficiency and Nkx2-5 hypomorphic models vs. Wild-type mice was evaluated on Formation and identity of the pulmonary myocardium. Pitx2c is required for the initial formation of pulmonary myocardial cells, while Nkx2-5 determines their distinct identity compared to the systemic venous return.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: