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BACKGROUND: Circular RNAs (circRNAs) play important roles in regulating the radioresistance of esophageal squamous cell carcinoma (ESCC). This study aimed to determine the role of hsacircRNA₁00367 in regulating radioresistance of ESCC. RESULTS: , circRNA₁00367 silence reduced the growth of KYSE-150R cells under radiation. CONCLUSION: Our results revealed that circRNA₁00367 attenuated radioresistance of ESCC through miR-217/Wnt3 pathway. METHODS: CircRNAs related with the radioresistance of ESCC were analyzed by hierarchical cluster analysis. The relationship between circRNA₁00367 and miR-217, Wnt3 was detected by RNA immunoprecipitation (RIP), RNA pull-down and luciferase reporte assays. The proliferation and migration ESCC cells were detected by MTT, Transwell and colony formation assays.
Liu et al. (Wed,) studied this question.