Generation of 4 human induced pluripotent stem cell lines (LUMCi070-A, −B, −C, and −D) from a patient with ischemic cerebral small vessel disease

Bas J. B. Voesenek; Linda M. van der Graaf; Saskia A.J. Lesnik Oberstein; Willeke M.C. van Roon-Mom; Elena Daoutsali; Ronald A.M. Buijsen

doi:10.1016/j.scr.2026.104036

June 1, 2026Stem Cell ResearchOpen Access

Generation of 4 human induced pluripotent stem cell lines (LUMCi070-A, −B, −C, and −D) from a patient with ischemic cerebral small vessel disease

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Key Points

To generate and characterize induced pluripotent stem cells (iPSCs) from a patient with ischemic small vessel disease.
Generated four human iPSC lines (LUMCi070-A, B, C, and D) from a patient.
Characterized the iPSCs for expression of pluripotency markers at RNA and protein levels.
Assessed the capacity of iPSCs to differentiate into all three germ layers.
iPSCs expressed key pluripotency markers indicating successful generation.
Demonstrated ability to differentiate into all three germ layers.
iPSCs can be utilized to explore the underlying mechanisms of ischemic small vessel disease.

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Implication

Study generated pluripotent stem cells in a patient with ischemic small vessel disease, suggesting new research avenues for therapies.

Abstract

We generated induced pluripotent stem cells (iPSCs) from a patient with ischemic small vessel disease carrying a likely pathogenic variant in the APP gene. These iPSCs show expression of pluripotency markers on RNA and protein level, as well as the ability to differentiate into all three germ layers. They can be used to investigate disease mechanisms and support the development of new therapies.

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Voesenek et al. (2026) studied this question.

synapsesocial.com/papers/6a3238acd50b63ecad204835 https://doi.org/10.1016/j.scr.2026.104036

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Generation of 4 human induced pluripotent stem cell lines (LUMCi070-A, −B, −C, and −D) from a patient with ischemic cerebral small vessel disease

Key Points

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Implication

Abstract

Discussion

Cite This Study

Generation of 4 human induced pluripotent stem cell lines (LUMCi070-A, −B, −C, and −D) from a patient with ischemic cerebral small vessel disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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