Minimally invasive treatments such as fractional lasers are well-established options for addressing the aging skin in the periorbital region. Among energy-based devices, radiofrequency microneedling (RFMN) has emerged as a potential alternative. To evaluate the effectiveness and safety of RFMN for periorbital rejuvenation. In this prospective, evaluator-blinded clinical study, patients with periorbital wrinkles and fine lines received 1-3 RFMN sessions at 6-8-week intervals. Follow-up occurred 6 months after the final treatment. Outcomes were assessed using automated imaging software and a 5-point numeric rating scale (1 = very much improved; 5 = worsened) by two blinded, board-certified dermatologists. Adverse events (AEs) were documented. In total, 25 patients were included. Imaging analysis showed mean wrinkle reduction of 25.3 ± 40.4% in the infraorbital area and 37.3 ± 64.0% in the crow's feet region. Blinded evaluators reported a mean clinical score of 3.21 ± 0.98, reflecting variable improvement. All patients experienced transient erythema and edema, resolving within days. No severe AEs occurred. RFMN appears to be a promising option for periorbital rejuvenation with minimal downtime. Larger comparative studies are needed to confirm efficacy and define its role relative to established treatments.
Nguyen et al. (2026) studied this question.