Randomized trial examines anticancer and antimicrobial effects of five Vachellia species leaf extracts, suggesting therapeutic potential for infection management.
Key Points
This study aims to evaluate the phytochemical profiles and bioactive potential of leaf extracts from various Vachellia species against cancer and microbial infections.
Investigated phytochemical composition using FTIR and GC-MS.
Assessed cytotoxicity in MCF-7 and HCT116 cancer cell lines and MRC5 normal cells.
Evaluated antimicrobial activity against S. aureus, E. coli, and C. albicans.
V. karroo and V. xanthophloea showed strong cytotoxicity with IC50 values of 9.61 ± 1.00 and 9.82 ± 0.96 μg/mL against MCF-7 cells.
All extracts demonstrated low cytotoxicity towards MRC5 cells (IC50 > 20 μg/mL).
V. karroo presented MIC values of 1.25, 2.50, and 5.00 mg/mL against S. aureus, E. coli, and C. albicans, respectively.