An extract from amazonian fruit, camu-camu (Myrciaria dubia), attenuates DSS-induced gut-liver axis alterations by improving intestinal morphology and barrier-related gene expression and reducing hepatic histological damage and oxidative stress in ovo (Gallus gallus).

day). Results showed that camu-camu was associated with changes in intestinal histomorphology, increasing villus height, surface area, and the number of goblet cells, along with increased expression of selected barrier-related genes (MUC2, CLDN-1, and ZO-2). In the liver, camu-camu significantly reduced NF-κB expression compared to the DSS and water-treated groups, consistent with modulation of inflammatory-related gene expression. Furthermore, the decreased expression of iNOS, CAT, and SOD-1 indicates modulation of oxidative stress-related gene expression markers. Histological analysis indicated alterations in hepatic morphology, including reduced lipid droplets and inflammatory infiltrates. These findings indicate that camu-camu is associated with changes in intestinal histomorphology, selected barrier-related gene expressions, hepatic histology, and inflammatory- and oxidative stress-related gene expression markers.