What question did this study set out to answer?

The aim is to develop efficient methods for synthesizing 2,2-disubstituted indolin-3-ones, which are significant in both structural and biological contexts.

June 17, 2026Advanced Synthesis & Catalysis

Chemoselective Synthesis of 2,2‐Disubstituted Indolin‐3‐Ones via Palladium‐Catalyzed Allylation of 3‐Hydroxyindoles

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Authors

CYChi YangUniversity of Science and Technology of China QZQi ZhangJinan University LGLeyang GuanChina Pharmaceutical University

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Overview

Randomized trial demonstrates efficient synthesis of indolin-3-ones in organic chemistry, suggesting new methods for diverse transformations.

Key Points

The aim is to develop efficient methods for synthesizing 2,2-disubstituted indolin-3-ones, which are significant in both structural and biological contexts.
Utilized palladium-catalyzed allylation of 3-hydroxyindoles with internal alkynes and gem-difluorocyclopropanes.
Employed redox-neutral conditions for direct synthesis of 2-allyl-2-carboxylate-indolin-3-ones.
Demonstrated broad substrate scope and excellent functional group tolerance.
Successfully synthesized 2-allyl-2-carboxylate-indolin-3-ones under mild conditions with high yield.
Achieved introduction of fluorine atoms and construction of C2 all-carbon quaternary center in a single step.
Facilitated rapid access to complex biologically relevant heterocycles through downstream transformations.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a323bbcd50b63ecad206432 https://doi.org/10.1002/adsc.70587

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June 17, 2026Advanced Synthesis & Catalysis

Chemoselective Synthesis of 2,2‐Disubstituted Indolin‐3‐Ones via Palladium‐Catalyzed Allylation of 3‐Hydroxyindoles

View Full Paper

Ask AI

Bookmark

Authors

CYChi YangUniversity of Science and Technology of China QZQi ZhangJinan University LGLeyang GuanChina Pharmaceutical University

Discussion

Member takes

Overview

Randomized trial demonstrates efficient synthesis of indolin-3-ones in organic chemistry, suggesting new methods for diverse transformations.

Key Points

The aim is to develop efficient methods for synthesizing 2,2-disubstituted indolin-3-ones, which are significant in both structural and biological contexts.
Utilized palladium-catalyzed allylation of 3-hydroxyindoles with internal alkynes and gem-difluorocyclopropanes.
Employed redox-neutral conditions for direct synthesis of 2-allyl-2-carboxylate-indolin-3-ones.
Demonstrated broad substrate scope and excellent functional group tolerance.
Successfully synthesized 2-allyl-2-carboxylate-indolin-3-ones under mild conditions with high yield.
Achieved introduction of fluorine atoms and construction of C2 all-carbon quaternary center in a single step.
Facilitated rapid access to complex biologically relevant heterocycles through downstream transformations.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a323bbcd50b63ecad206432 https://doi.org/10.1002/adsc.70587

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