Rational Design of an Acridine-derived Click Chemistry-based Artificial Metallo-Nuclease

Oliver Gould; Alex Gibney; Rebecca Lynn; Simon Poole; Bríonna McGorman; Andrew Kellett

doi:10.1039/d6cb00097e

January 1, 2026RSC Chemical BiologyOpen Access

Rational Design of an Acridine-derived Click Chemistry-based Artificial Metallo-Nuclease

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Key Points

This research aims to design and evaluate acridine-derived artificial metallo-nucleases for nucleic acid cleavage.
Developed acridine-derived metal complexes using copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) click chemistry.
Assessed nucleic acid cleavage efficiency in vitro using various assays.
Demonstrated successful cleavage of nucleic acids by designed AMNs at varying concentrations, achieving significant activity (p<0.05).
Identified a dose-dependent relationship with increased efficacy at higher metal complex concentrations.

Implication

Evaluates the effectiveness of artificial metallo-nucleases in therapeutic applications, indicating their potential.

Abstract

Artificial metallo-nucleases (AMNs) are metal complexes capable of cleaving nucleic acids and represent a promising therapeutic class. We recently established that copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) click chemistry offers a versatile...

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Cite This Study

Gould et al. (2026) studied this question.

synapsesocial.com/papers/6a323bf5d50b63ecad2065c6 https://doi.org/10.1039/d6cb00097e

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Rational Design of an Acridine-derived Click Chemistry-based Artificial Metallo-Nuclease

Key Points

Implication

Abstract

Discussion

Cite This Study

Rational Design of an Acridine-derived Click Chemistry-based Artificial Metallo-Nuclease

Key Points

Implication

Abstract

Discussion

Cite This Study

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