Hypertension Worsens Bone Loss and Weakens Bone in Aged Ovariectomized Mice

June 15, 2026JBMR PlusOpen Access

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The study aims to investigate how ovariectomy-induced estrogen loss and hypertension affect bone strength in mice.
Twelve-month-old C57BL/6J mice underwent ovariectomy or sham surgery.
Mice received an infusion of angiotensin II or vehicle to induce hypertension for six weeks.
Blood pressure and bone mineral density were monitored before and after treatments.
Ovariectomy significantly decreased whole-body bone mineral density.
Hypertension reduced femur cortical bone area and thickness in the ovariectomized group.
Combined OVX-hypertension significantly weakened lumbar vertebra strength compared to OVX or hypertension alone.

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Reveals that hypertension worsens bone loss in aged ovariectomized mice, indicating increased fracture risk.

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Hennen et al. (2026) studied this question.

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