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June 17, 2026Acta NeuropathologicaOpen Access

Expression of GPR34 in microglia remains stable in human Alzheimer’s disease

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Authors

SSSophie SeifferJRJonas RotterJBJana Brendler

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Overview

Randomized trial examines microglial GPR34 expression in Alzheimer's disease, suggesting context-dependent regulation.

Key Points

  • This research aims to investigate the expression of GPR34 in microglia and its relation to pathology in Alzheimer's disease.
  • Conducted quantitative analysis of microglial density, morphology, and GPR34 expression in the medial temporal lobe cortex of elderly donors.
  • Analyzed data from 187,670 microglial cells using fluorescence in situ hybridization and immunolabeling.
  • Assessed human single-nucleus RNA sequencing data from 236,002 cells for GPR34 expression across different microglial subtypes.
  • Microglial density and overall morphology in the medial temporal lobe cortex remained stable despite Aβ and tau pathology.
  • GPR34 expression showed significant variability among microglial subtypes and brain regions.
  • No consistent correlation was found between GPR34 expression and Alzheimer's disease pathology stages.

Cite This Study

Seiffer et al. (2026) studied this question.

synapsesocial.com/papers/6a323cc9d50b63ecad206db2https://doi.org/10.1007/s00401-026-03035-0
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