Cross-sectional study examines kidney function and nutrition effects on homocysteine in older adults, suggesting their independent roles in metabolic risk.
Key Points
This study aims to explore the relationships among estimated glomerular filtration rate, nutritional factors, and homocysteine levels in older adults.
Cross-sectional design involving participants aged ≥ 65 years
Biochemical measurements of homocysteine, folic acid, vitamin B 12, and eGFR calculation
Statistical analyses using regression to examine associations
Lower eGFR groups showed significantly higher homocysteine levels: 16.9 vs. 11.9 vs. 9.3 μM (p < 0.01)
Each 1-unit decrease in eGFR associates with increased homocysteine (β = -0.13, p < 0.01)
Higher folic acid and vitamin B 12 correlate with decreased homocysteine levels (β = -0.29 and β = -0.003, p < 0.01)