Exploring the mechanism of mulberry leaf compound in treating obesity based on network pharmacology and molecular docking

June 1, 2026Lishizhen medicine and materia medica research

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The research aims to explore the mechanisms by which mulberry leaf compound affects obesity through network pharmacology and experimental validation.
Utilized database screening to identify active compounds and targets from mulberry leaf compound.
Constructed component-target and PPI networks, followed by GO and KEGG enrichment analysis.
Established a high-fat diet-induced obesity rat model with six treatment groups for six weeks.
Identified 67 active compounds and 171 intersection targets, with core targets including TNF, VEGFA, and PPARG.
Enrichment analysis revealed significant pathways such as PI3K/Akt and insulin resistance.
Animal studies demonstrated that mulberry leaf compound significantly reduced body weight and improved glucose-lipid metabolism metrics (P<0.05).

Investigates the effects of mulberry leaf compound on obesity, suggesting multi-target mechanisms for treatment.

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鲍娟 et al. (2026) studied this question.

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