PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
June 17, 2026Stem Cells InternationalOpen Access

Amentoflavone Suppresses Stemness of Retinoblastoma Cell via Targeting Smoothened (SMO) Protein

View Full Paper
Ask AI
Bookmark
Share

Authors

CLCuiping LiXYXin YuXKXiangfen Kong

Discussion

Loading...

Member takes

Overview

Randomized trial investigates amentoflavone's impact on retinoblastoma stem cells, suggesting a novel therapeutic approach.

Key Points

  • This research aims to evaluate amentoflavone's effect on stemness in retinoblastoma and its underlying mechanisms.
  • Conducted CCK8 assays, migration and invasion assays, and tumorsphere formation assays.
  • Performed qRT-PCR to assess stem cell markers expression and RNA sequencing for mechanism exploration.
  • Utilized molecular docking and surface plasmon resonance to identify amentoflavone's target.
  • Amentoflavone significantly reduces stemness markers (CD44, CD133, Oct4, Nanog) in a dose-dependent manner.
  • In vivo studies showed that amentoflavone inhibits tumor metastasis and prolongs survival in RB mouse models.
  • Amentoflavone directly targets smoothened (SMO), disrupting the SHh signaling pathway.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a323e36d50b63ecad207927https://doi.org/10.1155/sci/7261941
View Full Paper
Ask AI
Bookmark
Share