Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 17, 2026European Journal Of Haematology

Is There a Difference in Occurrence of Complications Between Adults With Hemoglobin SS and Hemoglobin SC Disease: An Extended Systematic Review

View Full Paper
Ask AI
Bookmark
Share

Authors

MMMartijn van der MeerKVKim VelsinkWTWing H. Tong

Discussion

Loading...

Member takes

Overview

Extended systematic review highlights differences in complications between sickle cell genotypes, suggesting targeted management strategies.

Key Points

  • This review aims to compare the types of complications that arise in adults with Hemoglobin SS and SC genotypes of sickle cell disease.
  • Systematic review conducted per PRISMA guidelines, examining a total of 710 references
  • Excluded 521 records based on title, abstract, and criteria, leading to analysis of 31 relevant studies
  • Focus on differences in acute and chronic complications between HbSS and HbSC genotypes.
  • Vaso-occlusive crises are more frequent in HbSS patients compared to HbSC patients
  • Chronic complications are more prevalent in the ocular and pulmonary systems for HbSC patients
  • Both genotypes experience progressive organ damage due to recurrent ischemic injury and inflammation.

Cite This Study

Meer et al. (2026) studied this question.

synapsesocial.com/papers/6a323e36d50b63ecad20795fhttps://doi.org/10.1111/ejh.70239
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sickle Cell Disease2017 · 1,390 citations
  2. 2Global Burden of Sickle Cell Anaemia in Children under Five, 2010–2050: Modelling Based on Demographics, Excess Mortality, and Interventions2013 · 1,143 citations
  3. 3Osteonecrosis of the Humeral Head in Sickle Cell Disease1993 · 96 citations
  4. 4Sickle Cell Disease2022 · 480 citations
  5. 5A Systematic Review on the Management of Transfusion-Related Acute Lung Injury in Transfusion-Dependent Sickle Cell Disease2022 · 2 citations