The Interplay of Thyroid and Mind: A Case of Psychosis Secondary to Graves’ Disease

Graves' disease is an autoimmune thyroid disorder commonly associated with symptoms of hyperthyroidism, such as heat intolerance, palpitations, and tremors. Psychiatric manifestations are rare; they include anxiety, depression, delirium, toxic psychosis, and bipolar disorder. It can complicate the clinical picture and significantly impact a patient's quality of life. Psychosis, occurring in approximately 1% of cases, highlights the importance of recognizing the broader mental health effects of the disease. We report the case of a 47-year-old man with Graves' disease who developed psychosis secondary to thyrotoxicosis due to his failure to adhere to antithyroid medication. This non-compliance resulted in multiple psychiatric admissions. The worsening of his psychotic symptoms, driven by the ongoing thyrotoxicosis, led to the decision for a total thyroidectomy. This case highlights the complex relationship between thyroid dysfunction and psychiatric symptoms, emphasizing the importance of early diagnosis, medication adherence, and multidisciplinary co-management for optimal outcomes in patients with Graves' disease and psychiatric manifestations.