Answers are grounded in this paper and cite their sources.
Case report reveals a rare coexistence of granular cell tumor and gastric adenocarcinoma in a woman, suggesting new insights into tumor biology.
In a 41-yr-old Japanese woman, a rare coincident lesion composed of granular cell tumor and early gastric adenocarcinoma was detected in the stomach. Beneath the poorly differentiated adenocarcinoma almost limiting to the mucosa, the granular cell tumor measuring 1.2×0.8 cm was spreading mainly in the submucosa without forming polypoid nodule. To the best of our knowledge, this type of coincidence has been the first published report. Immunohistochemically, the cells of the granular cell tumor were strongly positive for S-100 protein, but negative for muscle markers (HHF 35, desmin), some of which connected with perineural Schwann cells surrounding small vessels in the submucosa. These features suggested that granuler cell tumor in our case arose from Schwann cells surrounding small vessels in the submucosa of the stomach.
No takes yet. Share an insight, caveat, or question.
Xuan et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: