INTRODUCTION: mutation carriers, and two other potentially high-risk mutations, TP53 and PALB2. METHODOLOGY: ' and 'surgery'. Fifteen articles were identified by searching and one article was obtained from other sources. RESULTS: are potentially high-risk mutations for breast cancer, which may justify the use of prophylactic surgery. Advice should be given on a case-by-case basis. CONCLUSION: A comprehensive approach is needed to provide optimum treatment for breast cancer patients with deleterious mutations.
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Song et al. (2018) studied this question.