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ABSTRACT The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii , Pseudomonas aeruginosa , Staphylococcus aureus , Klebsiella pneumoniae , and Escherichia coli . Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus . Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.
Thompson et al. (Tue,) studied this question.