Key result
First-hour circulating angiopoietin-2 concentrations were proportional to disease severity and predicted the future occurrence of shock or death (p < 0.0001) in patients with suspected infection.
Why the study?
Does angiopoietin-2 contribute to adverse outcomes and mortality in sepsis?
Observational (n=270)
No
Does angiopoietin-2 contribute to adverse outcomes and mortality in sepsis?
Angiopoietin-2 induction contributes to adverse outcomes and mortality in sepsis, suggesting it as a potential therapeutic target and prognostic biomarker.
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David et al. (2012) conducted an observational in Sepsis / suspected infection (n=270). Elevated circulating angiopoietin-2 vs. Lower circulating angiopoietin-2 was evaluated on Future occurrence of shock or death (p=<0.0001). First-hour circulating angiopoietin-2 concentrations were proportional to disease severity and predicted the future occurrence of shock or death (p < 0.0001) in patients with suspected infection.
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