Key result
Aging is linked to reduced respiratory heart rate modulation and less stable cardiorespiratory coupling.
Cross-Sectional (n=189)
Physiological cardiorespiratory coupling and respiratory sinus arrhythmia diminish and become less stable as humans age.
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Age-related decline in cardiorespiratory coupling stability may signal autonomic senescence; leaves open predictive value and intervention targets in longitudinal studies.
We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90. By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure. By treating the heart and respiration as coupled oscillators, we then apply a method based on Bayesian inference to find the underlying coupling parameters and their time dependence, deriving from them measures such as synchronization, coupling directionality and the relative contributions of different mechanisms. We report a detailed analysis of the reconstructed cardiorespiratory coupling function, its time evolution and age dependence. We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.
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Iatsenko et al. (2013) conducted a cross-sectional in Healthy (n=189). Age vs. Younger age was evaluated on Cardiorespiratory coupling directionality and respiratory modulation of heart rate. Direct and indirect respiratory modulations of the heart rate both decrease with age, and the cardiorespiratory coupling becomes less stable and more time-variable.
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